2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid

2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid - Names and Identifiers

Name	2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid
Synonyms	2-(4-Hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid 2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid 5-Pyrimidinecarboxylic acid, 2-(4-hydroxy-1-piperidinyl)-
CAS	1116339-69-5

2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid - Physico-chemical Properties

Molecular Formula	C10H13N3O3
Molar Mass	223.23

2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid - Risk and Safety

Safety Description	24/25 - Avoid contact with skin and eyes.
HS Code	29335990

2-(4-hydroxypiperidin-1-yl)pyrimidine-5-carboxylic acid - Introduction

2-(4-hydroxypiperidin-1-yl) pyrimidine-5-carboxylic acid (abbreviated as HMPA) is an organic compound. Its molecular formula is C12H14N2O3, the structural formula is as follows:

HMPA is a colorless or yellowish powdery solid that is soluble in water and many organic solvents. Its main properties and uses are as follows:

1. High polarity: HMPA is a strong polar solvent, which can promote the progress of many organic reactions, especially those involving proton transfer. It can promote the acid-catalyzed reaction and improve the reaction rate and yield.

2. ligand: HMPA can form a complex and metal ion coordination, promote the metal catalyzed reaction. It is often used as a ligand for organometallic compounds, such as synthetic organolithium compounds and organocopper compounds.

3. Charge separation solvent: HMPA can separate the positive and negative charges in solvent molecules, increase the interaction between reactants and products, and promote the dissolution of solutes.

In the preparation method, HMPA can be obtained by reacting 4-aminopyrrolidone with acetic anhydride, and then reacting with sodium hydroxide to generate 2-(4-hydroxypiperidin-1-yl) pyrimidine -5-formaldehyde, which is further reduced to obtain the target product.

Regarding safety information, HMPA is toxic and irritating to the skin and eyes. Wear protective gloves, goggles and other personal protective equipment during use to avoid contact with skin and inhalation. Should be properly stored, away from fire and oxidant, avoid contact with strong acid, alkali and other substances. At the same time, it should be used in a well-ventilated place, and attention should be paid to avoid inhaling its vapor. In case of accidental contact, rinse with water immediately and seek medical treatment.

Last Update：2024-04-10 22:29:15